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Proceedings of the National Academy of Sciences: Proceedings of the National Academy of Sciences: Table of Contents
Table of Contents for Proceedings of the National Academy of Sciences. List of articles from both the latest and ahead of print issues.
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In This Issue
Proceedings of the National Academy of Sciences, Volume 123, Issue 44, November 2026. <br/>
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Deep mutational scanning of the GPCR rhodopsin reveals pleiotropic mutational effects and their roles in modulating receptor signaling
Proceedings of the National Academy of Sciences, Volume 123, Issue 44, November 2026. <br/>SignificanceUnderstanding how genetic variation impacts protein function is an important but challenging area of research as many mutations are pleiotropic, simultaneously affecting multiple protein properties, including structure, stability, and ...
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Structural basis of glycoprotein recognition by the human folding sensor UDP-glucose:glycoprotein glucosyltransferase
Proceedings of the National Academy of Sciences, Volume 123, Issue 44, November 2026. <br/>SignificanceUDP-glucose:glycoprotein glucosyltransferase 1 (UGGT1) is the central folding sensor of the endoplasmic reticulum (ER) glycoprotein quality-control pathway, yet how it recognizes structurally diverse misfolded substrates has remained unclear. ...
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Mechanism of catalytic regulation by an allosteric hot spot in dihydrofolate reductase
Proceedings of the National Academy of Sciences, Volume 123, Issue 44, November 2026. <br/>SignificanceProteins can regulate their activity through allostery, in which a perturbation at one site, classically the binding of an effector but also a mutation, changes function at a distant site. How such a change reaches the reactive site remains ...
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Multiscale Brownian dynamics simulations reveal effects of macromolecular crowding on protein–ligand association
Proceedings of the National Academy of Sciences, Volume 123, Issue 44, November 2026. <br/>SignificanceMacromolecular crowding, such as the dense packing of biomolecules in cellular environments, can alter how proteins and small molecules interact, yet its effects on binding rates and pathways remain poorly understood. We developed a ...